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AP1

AP-1 (activating protein-1) is a collective term referring to dimeric transcription factors composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common DNA site, the AP-1-binding site.) AP-1 regulates a wide range of cellular processes, including cell proliferation, death, survival and differentiation.

Increased AP-1 levels lead to increased transactivation of target gene expression. Regulation of AP-1 activity is therefore critical for cell function and occurs through specific interactions controlled by dimer-composition, transcriptional and post-translational events, and interaction with accessory proteins. AP-1 functions are heavily dependent on the specific Fos and Jun subunits contributing to AP-1 dimers. The outcome of AP-1 activation is dependent on the complex combinatorial patterns of AP-1 component dimers. The AP-1 complex binds to a palindromic DNA motif (5’-TGA G/C TCA-3’) to regulate gene expression, but specificity is dependent on the dimer composition of the bZIP subunit.

AP1 Related diseases and targets
Article number
GM-C24819 GM-C24818
Product title
CD112-CD112R-3
Schedule
Build a complete
Build a complete
ap1 Related diseases and targets
Article number
GM-C24817
Product title
CD112-CD112R-3
Schedule
Build a complete
AP1 Related diseases and targets
Name
LMD-009
LMD-A
Type
C-C Chemokine Receptor Type 8 (CCR8) Ligands
C-C Chemokine Receptor Type 8 (CCR8) Ligands
Indications
Pharmacological Tools
Antiallergy/Antiasthmatic Drugs
AP1

AP-1 (activating protein-1) is a collective term referring to dimeric transcription factors composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common DNA site, the AP-1-binding site.) AP-1 regulates a wide range of cellular processes, including cell proliferation, death, survival and differentiation.

Increased AP-1 levels lead to increased transactivation of target gene expression. Regulation of AP-1 activity is therefore critical for cell function and occurs through specific interactions controlled by dimer-composition, transcriptional and post-translational events, and interaction with accessory proteins. AP-1 functions are heavily dependent on the specific Fos and Jun subunits contributing to AP-1 dimers. The outcome of AP-1 activation is dependent on the complex combinatorial patterns of AP-1 component dimers. The AP-1 complex binds to a palindromic DNA motif (5’-TGA G/C TCA-3’) to regulate gene expression, but specificity is dependent on the dimer composition of the bZIP subunit.

AP1 Related diseases and targets
Article number
GM-C24819 GM-C24818
Product title
CD112-CD112R-3
Schedule
Build a complete
Build a complete
ap1 Related diseases and targets
Article number
GM-C24817
Product title
CD112-CD112R-3
Schedule
Build a complete
AP1 Related diseases and targets
Name
LMD-009
LMD-A
Type
C-C Chemokine Receptor Type 8 (CCR8) Ligands
C-C Chemokine Receptor Type 8 (CCR8) Ligands
Indications
Pharmacological Tools
Antiallergy/Antiasthmatic Drugs
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